Dan Theodorescu, MD, Ph.D. is the Director of the National Cancer Institute (NCI) designated Comprehensive Cancer Center at the University of Colorado where he is also a Distinguished University Professor. Dan is known for his work on the molecular mechanisms underlying bladder cancer and tools that determine drug response as well as discovery of new drugs for cancer. Examples include discovery of genes that regulate tumor growth and metastasis and concepts for precision therapeutic approaches such as the COXEN principle, that are currently being tested in national clinical trials. He also conceptualized the approach and then led the discovery of a “first in class” RalGTPase inhibitor as a new therapeutic in cancer currently in commercial development.