2010
Time: The Crucial Fourth Dimension of Personalized Medicine
During the U.S. healthcare deliberations, the words invention, technology, diagnostics, and wellness were mentioned rarely, if ever. No one said “revolution in healthcare” and yet a healthcare revolution is underway. Never before could a physician peer into the body, blood, or DNA of a patient and “see” the risk of disease for that person or “see” a disease at such an early stage that intervention might be crucial. That vision defines personalized medicine, which includes actionable measurements of genotype and phenotype – DNA and proteins.
For the inaugural symposium, Gold Lab invited medical and scientific thought leaders and stakeholders to debate and inform each other and the audience on how best to facilitate the most timely transformation of medicine. “Our motivation is simple,” said Dr. Larry Gold, Professor, MCDB, University of Colorado and CEO of SomaLogic, “Scientists are responsible for innovations; scientists also must participate in discussions that enable the timely use of those innovations. An informed citizenry is at the heart of an improved healthcare system.”
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Opening Remarks 2010
Today Personalized Medicine is available, technically, and yet the infrastructure needed for full implementation is inadequate, the challenges are large, and society is unready for (perhaps even hostile to) what is possible.
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Personalized Medicine Technologies: Omics for Everyone
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Human Genetics and Disease
The past 30 years have seen a revolution in knowledge of the basis of genetic disease. Progress towards identifying the genetic causation of complex disease will be considered in the context of the strengths, weaknesses, and flaws of these experimental approaches, with a view towards the near future based on high-throughput DNA sequencing of candidate genes and full genomes.
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Protein Biomarkers: A Blood Test for Early Stage Non Small Cell Lung Cancer
Lung cancer is the leading cause of cancer deaths in the U.S. at 160,000/year because most cases are diagnosed in later stages and the disease is histologically heterogeneous. New clinically effective diagnostic methods are urgently needed to identify lung cancer in earlier stages when surgical resection has the potential for curative therapy. A blood protein biomarker panel has the potential...
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Monitoring Wellness: Blood Tests for Many Diseases
The dream of transforming medical practice by measuring individualized actionable medical and lifestyle data for all common conditions from a single blood test has not been realized. Obstacles to accomplishing it are technical, human, and economic. Nonetheless, there is a glimmer of hope; new techniques such as SomaLogic’s 850-plex proteomic assay can overcome some of these obstacles with the potential that early versions of the wellness chip could be 5 years away.
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Time: Personalized Medicine’s Final Frontier
Despite current excitement, the truth is that medicine has always been “personalized.” However, traditional personalized medicine has been based on both an extremely limited knowledge of presenting phenotype and an even more limited number of effective therapeutic possibilities.
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Diagnostic Information, Connectedness, and Drugs: Systems Infrastructures
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Sustaining Healthcare Innovation in an Era of Constraint
Rapid progress in molecular biology offers the promise of major gains in the detection, treatment, and prevention of diseases and for targeting therapeutic interventions to match the molecular and pharmacogenetic profiles of individual patients (personalized medicine). However, the anticipated acceleration of new discoveries will also generate complex economic, social, and ethical questions regarding the ‘value’ of innovation, how much new...
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Diagnostics in the Reference Labs: Putting the Patient First
Technologies are rapidly maturing, which enable evaluation of disease-specific and informative molecules with high sensitivity and on a large scale. The rate of new marker discovery is therefore advancing rapidly and so focus on diagnostics with high value for individual patients is at risk of being lost in scientific excitement – more is not necessarily better.
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The Healthcare Ecosystem: Connecting the Parts
The wireless industry is revolutionizing Life Sciences by partnering with medical device companies to create innovative, connected health solutions. Wireless body-worn sensors, environmental sensors, medical implants, and smart phone apps are increasing the efficacy and efficiency of medical solutions.
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Improved Interventions: Drug Use and Best Practices
Medco is a leading pharmacy benefit manager (PBM), with the nation’s largest mail order pharmacy operations. Through advanced pharmacy, Medco improves the health and lowers the total cost of care for clients and their members, helping to ensure that millions of Americans have access to affordable, high-quality prescription healthcare.
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A guided discussion with panelists led by Tom Cech
A guided discussion with panelists led by Tom Cech, Ph.D., Professor, University of Colorado, former President, HHMI
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Perspectives: Challenges to Change
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Patient-Centered Care Perspectives: Views from Where We Stand, Sit, and Lie Down
There’s a lot of buzz these days about patient experience. Lots of talk about becoming the Apple, Nordstrom, or Starbucks of health care. But what is the “patient’s perspective” and how is it relevant to the care provided? Consider how a deeper understanding of patient experience can inform care delivery, and ultimately improve care outcomes.
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Pathway-Specific Medicines: 21st Century Solutions to Unmet Medical Needs
Cancer remains one of the great unmet medical needs with high morbidity and mortality. Older therapies relied upon exceedingly toxic methods, such as chemotherapy and radiation, which had marginal therapeutic indices. This talk will discuss the approaches utilized by three early-stage biotechnology companies who hope to further explore other oncogenic pathways that may be involved in a large number of tumors.
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The Parent Project: Advocating for Children’s Health
Parents have children. They notice things, little things that just seem to separate their child from other children. They express these concerns to their healthcare providers and are often dismissed for months or sometimes years. This talk will focus on the stakeholders and the tools they utilize for success: Leadership development, Coalition building, Networking, Political lobbying, and leveraging support –...
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The Gardasil Story: A Vaccine to Prevent Cervical Cancer
Human Papillomavirus (HPV) is a potent carcinogen strongly linked with cervical cancer, but which also causes other benign and malignant diseases such as genital warts, and vulvar, vaginal, penile, and head and neck cancers. In this presentation, the clinical efficacy and safety of the quadrivalent HPV vaccine will be reviewed, and future implications will be discussed.
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Societal Dimensions: Healthcare in the Promised Land
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A New Moral Vision for Health Care
American health policy has missed a crucial point. Medical ethics may control the behavior of health providers, but it should not control the macro-allocation process. Public policy must have its own independent ethical duties. Welcome to the Brave New World of Health Care that is fast heading our way.
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Personalized Medicine: Facilitating a Partnership with the FDA
The path to personalized medicine traverses a largely uncharted legal and regulatory landscape that offers both challenge and opportunity. As we advance rapidly into an era of medical treatment tailored to individuals with information from increasingly sophisticated diagnostic tests, the FDA and other regulators are faced with a new paradigm that includes labeling of approved drugs with companion diagnostics and the co-development of drugs and companion tests.
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New World. New Doctors. New Training
The medical curriculum in this country emerged from a document written 100 years ago. Medical schools have built upon this scaffolding, improved curricula, and adapted to mind-boggling biomedical advances. Yet before our eyes, emerging global networks are bringing to health care a new and breathtaking change.
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Growing Pains: The Evolution Toward Consumer-Driven Medicine
Advances in molecular science and personalized medicine will further increase consumer demand. Private investors are seeking promising opportunities in care delivery. Major non-healthcare players are looking for opportunities to bring their know-how in scale, high performance, and technology infrastructure to health care. In this talk, several critical barriers will be identified, and approaches to addressing them discussed.
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Closing Remarks
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Closing Remarks 2010
Larry Gold delivers the closing remarks for the inaugural symposium.
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