Using Molecular Pathways of Omega-3 Fatty Acids to Block Inflammatory and Neuropathic Pain

Increasing evidence suggests that resolution of acute pain is an active molecular process and requires the production of specialized pro-resolving mediators (SPMs). SPM superfamily, including resolvins, protectins, and maresins, are derived from omega-3 fatty acids DHA and EPA. Ru-Rong will present evidence that synthetic SPMs produce potent analgesic actions in animal models of acute pain and chronic pain after inflammation, surgery, and nerve injury. He will also demonstrate the mechanisms by which SPMs control pain via neuronal, glial, and immune regulations. He will also discuss new SPM receptors that mediate the pro-resolution, anti-inflammatory, and analgesic actions of SPMs.