Anna Marie Pyle is the William Edward Gilbert Professor of Molecular, Cellular and Developmental Biology, professor of chemistry at Yale University, and an investigator with the Howard Hughes Medical Institute.
Pyle studies RNA structure and RNA recognition by protein enzymes. Her lab uses a combination of experimental biochemistry and crystallography to study the architectural features of large RNA molecules, such as self-splicing introns and other noncoding RNAs. This is accompanied by complementary work on RNA-dependent ATPase enzymes that bind and remodel RNA structures, with an emphasis on proteins that are involved in viral replication and host innate immune response. She was a postdoctoral fellow in the laboratory of Thomas R. Cech at the University of Colorado Boulder. She received a Ph.D. in chemistry under the direction of Jacqueline K. Barton at Columbia University.