Discovery Through Scale. The All of Us Research Program.

The NIH All of Us Research Program is working to advance precision medicine by building the largest, most diverse biomedical data resource in the world. Launched in May 2018, All of Us seeks to gather health data from one million or more participants across the United States, representing a wide array of backgrounds, ages, geographic regions, and health statuses.

All of Us has more than 750k consented participants, 85% of whom are underrepresented in biomedical research. With biosamples for more than 550k participants, we have made available 245k whole genome sequences, including 1,000 long-read sequences. We have made available electronic health records for more than 250k participants.

The data is available on the All of Us Researcher Workbench, which has more than 10k registered researchers, including researchers from six continents. Researchers have produced more than 400 publications, including promising discoveries in genomics, risk prediction, health disparities, and activity measurement.

Chris will discuss the innovative technologies and methodologies employed by the program, including electronic health record integration, genomics through whole genome sequencing, and mobile health data collection. These elements are instrumental in creating a comprehensive health database that supports a broad spectrum of research endeavors aimed at understanding and improving health outcomes.

Challenges such as data security, participant privacy, and maintaining engagement over the long term will be addressed, along with the solutions and safeguards that have been implemented. We will also explore how the program is facilitating access to its diverse dataset for researchers internationally, which is already enabling new health insights and discoveries.