Genetic variation, epigenetic regulation, and major environmental stimuli are key contributors to phenotypic variation, but the influence of minor perturbations or “noise” has previously been difficult to assess in mammals. By using armadillos as a model, we control for genetic and environmental factors and reveal early developmental stochasticity as a major source of variability between individuals.
Matt Might is an active advisor to the newly established Undiagnosed Disease Network Coordinating Center at Harvard University. He is passionate about patient-driven precision medicine, accelerating drug development in rare diseases, and bending the cost curve in medical research with computation and social media. He recently co-authored a white paper for the President’s precision medicine initiative.
Kevin Davies is the founding editor of Bio-IT World and Nature Genetics, and the author of The $1,000 Genome (Free Press, 2010), an account of the revolution in DNA sequencing technologies, personal genomics, and personalized medicine.
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