For too long in America health has been defined as simply not being sick.
One of society’s greatest challenges today is to improve health and achieve health equity for all at lower cost. I will speak about the plan of the Colorado Longitudinal Study (COLS) to create the largest, longitudinal repository of biological specimens and associated community and public health data in the world. I will discuss how we plan to recruit one million participants in Colorado to donate blood and urine annually for a 10-year period. COLS will also ask participants to provide comprehensive information about their health, behaviors, mood, and environment over time allowing researchers to study the interaction between biology and lifestyle in unprecedented ways. The impact of this will be more than additive, it will be multiplicative.
At the 2010 GoldLab Symposium, I discussed the challenges facing medical care systems as they try to build physician-centric primary care systems. Shortages of trained physicians force a rethinking of traditional solutions. Emerging technologies provide a host of new ways to respond.
Targeted nucleases, which include zinc finger nucleases and CRIPSR/Cas9, are poised to revolutionize gene therapy by potentially offering safer and more precise methods to engineer human genes.
Why has drug discovery become less efficient as the technologies that most people think are important have improved spectacularly?
There is a surprising amount of controversy about the contents of the human genome: junk DNA, pervasive RNA transcription, the role of long noncoding RNAs, and whether 20,000 protein-coding genes suffice to account for the complexity of our biology.